A-PvP (Flakka) For Sale

Buy A-PVP Powder Online: A Potent Pyrovalerone-Class Research Tool

At Research Stimulants, we deliver exceptional research chemicals to qualified laboratories, neuroscientists, pharmacologists, and academic institutions globally. Our A-PVP powder (α-Pyrrolidinopentiophenone, also known as alpha-PVP, flakka, or gravel) is a cornerstone synthetic cathinone in the pyrovalerone family, renowned for its high potency as a dopamine and norepinephrine reuptake inhibitor.

Developed originally in the 1960s and later resurfacing as a designer/research compound, αPVP serves as a critical reference for studying selective catecholamine transporter blockade, locomotor activation, and stimulant mechanisms. Researchers aiming to buy A-PVP powder receive our fine white to off-white crystalline product with ≥98% purity, verified through independent third-party HPLC, GC-MS, and NMR analysis. Every batch includes a full Certificate of Analysis (COA) for structural confirmation and quality assurance.

Important Disclaimer: All products from Research Stimulants, including A-PVP powder, are sold exclusively for legitimate laboratory and scientific research. They are not for human consumption, veterinary use, or therapeutic purposes. Handling is restricted to qualified professionals in controlled environments.

What is A-PVP? 

α-Pyrrolidinopentiophenone (α-PVP) is a synthetic cathinone with the systematic name 1-phenyl-2-(pyrrolidin-1-yl)pentan-1-one. Molecular formula: C₁₅H₂₁NO Molecular weight: 231.33 g/mol CAS Number: 14530-33-7 (freebase) / 5485-65-4 (HCl salt)

Chemically, α-PVP is the desmethyl analog of MDPV (3,4-methylenedioxypyrovalerone) and features a pyrrolidine ring at the alpha position and a pentyl chain. This structure confers potent, selective inhibition of the dopamine transporter (DAT) and norepinephrine transporter (NET), with IC₅₀ values typically in the 13–80 nM range for DAT and 14–70 nM for NET, while showing negligible activity at the serotonin transporter (SERT).

In research settings, A PVP powder (supplied as hydrochloride salt) appears as a fine white to off-white crystalline solid, highly soluble in water and polar solvents. Its pharmacological profile closely resembles cocaine and MDPV, making it invaluable for comparative studies of psychostimulant mechanisms.

Chemical Properties and Structure Overview

A-PVP features a phenyl ring attached to a pentan-1-one chain with a pyrrolidine moiety at the alpha carbon, creating a β-keto-pyrrolidinophenone structure.

Key properties include:

• Appearance: Fine white to off-white crystalline powder (HCl salt)
• Melting point (HCl salt): Approximately 161–165°C
• Solubility: Highly soluble in water, ethanol, DMSO
• Stability: Store in cool, dry, dark, airtight conditions for up to 24 months

The pyrrolidine ring enhances lipophilicity and DAT/NET selectivity compared to non-pyrrolidine cathinones. Our powder is produced under controlled conditions to minimize impurities.

For queries on “A-PVP chemical properties,” “alpha-PVP structure,” or “α-Pyrrolidinopentiophenone research,” Research Stimulants provides comprehensive specs, SDS, and analytical reports.

Research Applications of A-PVP Powder

A-PVP powder excels in neuropharmacology for modeling potent, selective DAT/NET inhibition and its consequences on reward, locomotion, and potential neurotoxicity.

Key applications include:

• Dopamine/norepinephrine transporter binding, release, and inhibition assays
• Behavioral studies of hyperlocomotion, stereotypy, and reinforcement in rodent models
• Comparative pharmacology with MDPV, cocaine, methamphetamine, and related pyrovalerones
• Investigations into excited delirium-like states, aggression, and psychosis models
• Forensic reference standards for NPS detection and metabolite identification

Preclinical data highlight A-PVP’s robust locomotor stimulation (blocked by D1/D2 antagonists) and elevated striatal dopamine levels, making it ideal for dissecting catecholamine-mediated stimulant effects.

The powder format enables accurate stock solution preparation and low-dose experiments.

Safety, Handling, and Legal Considerations

Handle A-PVP powder with extreme caution: Use full PPE, certified fume hoods, and ventilation. Risks include irritation, cardiovascular strain, hyperthermia, and autonomic effects from exposure.

Dispose according to hazardous waste protocols. Seek immediate medical attention for exposure.

Legally, α PVP is a Schedule I controlled substance in the United States (permanent placement in 2017), Schedule II under UN conventions in many countries, and prohibited in the EU, UK (Class B), Australia (Schedule 9), Canada, China, and most jurisdictions worldwide. Research Stimulants supplies only to verified research institutions with appropriate licensing and compliance documentation—no shipments to restricted areas or individuals.

Why Choose Research Stimulants for A-PVP Powder?

We differentiate with:

• ≥98% purity, third-party verified powder
• Comprehensive COA and supporting documentation
• Discreet, tracked global shipping
• Competitive pricing with bulk options
• Expert technical support and research resources

Researchers note: “Outstanding purity and consistency for DAT-focused transporter studies,” – Dr. S. L., neuropharmacologist.

Related products: MDPV Powder, α-PHP Powder, Pyrovalerone Analogs Guide.

Frequently Asked Questions (FAQs) About A-PVP Powder

What purity is your A-PVP powder? ≥98%, third-party lab-verified with COA.

How does A-PVP differ from MDPV? A-PVP lacks the 3,4-methylenedioxy ring, resulting in even higher DAT/NET selectivity and negligible SERT activity.

Storage recommendations for APVP powder? Cool, dry, dark, airtight container (2–8°C recommended).

Is A-PVP for non-research use? No—strictly laboratory research; all orders screened and verified.

Payment and shipping options? Secure methods (including crypto); fast, discreet delivery.

Samples available? Limited for qualified institutional researchers—contact us directly.

Elevate your synthetic cathinone and dopamine transporter research with premium A-PVP powder from Research Stimulants. Optimized for keywords like “buy A-PVP powder online,” “alpha-PVP research chemical,” “α-Pyrrolidinopentiophenone powder,” and “flakka research.” Order today!