Buy O-DMST Powder—High-Purity O-Desmethyltramadol Research Chemical | Research Stimulants

Research Stimulants delivers pharmaceutical-grade O-DMST powder (O-desmethyltramadol), the active tramadol metabolite optimized for advanced opioid receptor characterization and analgesic mechanism studies. This fine white hydrochloride powder ensures exceptional purity and aqueous solubility, perfect for biased agonism assays, dual MOR/NET pharmacology investigations, and pharmacokinetic profiling. Exclusively for licensed laboratory research applications.

Key Features

• Reference Standard Purity: ≥99% purity confirmed by chiral HPLC, LC-MS/MS, NMR analysis.

• Micronized Powder Morphology: Rapid dissolution (>50 mg/mL water) for quantitative assays.

• Institutional Quantities: 100mg analytical references to multi-gram research batches.

• Complete Documentation: Chiral CoA, impurity profiles <0.1%, detailed SDS provided.

O-DMST powder represents the gold standard for atypical opioid metabolite research.

What is O-DMST Powder?

O-Desmethyltramadol hydrochloride (O-DMST HCl; CAS 80456-81-1) features selective O-demethylation of tramadol yielding the potent (+/-)-enantiomeric pair with dual pharmacology. Formula C15H23NO2·HCl, molecular weight 285.81 g/mol. White crystalline powder, pKa 9.05, logP 2.3, highly water soluble with characteristic UV λmax 272 nm. The (-)-enantiomer delivers G-protein biased mu-opioid agonism (MOR Ki ~7 nM), while (+)-O-DMST inhibits norepinephrine transporter (NET Ki 0.8 μM).

Distinguishes from tramadol by 200-400x greater MOR potency and absent SERT activity, making it ideal for dissecting biased signaling pathways.

Research Applications

O-DMST powder powers innovative opioid studies at Research Stimulants:

• Biased Agonism Characterization: βarr2:G-protein bias ratio >10:1 via BRET/pathHunter assays.

• Synergistic Analgesia Modeling: Spinal MOR-NET co-activation synergy studies.

• Metabolite Pharmacodynamics: CYP2D6 phenotype research equivalents.

• Tolerance/Dependence Profiling: Reduced desensitization vs balanced MOR agonists.

Rodent tail-flick models confirm analgesia ED50 1.2 mg/kg SC with 12:1 therapeutic index over respiratory depression.

Unique bias profile minimizes classic opioid adverse effects.

Why Choose Research Stimulants?

Research Stimulants manufactures O-DMST powder via optimized demethylation with chiral characterization ensuring reproducible enantiomeric ratios across batches. Desiccated nitrogen-purged packaging prevents hydrolytic degradation. Research institutions prefer our batch-matched reference standards, expedited institutional transfer protocols, and competitive bulk pricing for long-term studies.

Dual MOR/NET mechanism eliminates serotonin confound present in parent tramadol research.

Usage Guidelines for Research

Laboratory optimization protocols:

• Storage: 2-8°C airtight amber vials; >36 month stability.

• Preparation: PBS pH 7.4 stock solutions (50 mg/mL); filter sterilize 0.22 μm.

• Assay Concentrations: 0.1-100 nM for binding, 1-1000 nM functional G-protein assays.

• Safety: Standard lab PPE; mild irritant (H315/319); adequate ventilation.

Technical specifications document microsomal stability t½ >2 hours, hERG IC50 >30 μM.

Effects Profile in Research Models

O-DMST powder signature pharmacology:

• G-Protein Biased MOR: Analgesia via Gi/o signaling with minimal β-arrestin/internalization.

• NET Inhibition Synergy: Spinal noradrenergic potentiation reduces hyperalgesia.

• Pharmacokinetics: Tmax 30-45 min SC, 85% bioavailability, moderate hepatic clearance.

• Safety Differentiation: Respiratory ceiling effect at 10x analgesic dose vs morphine.

Reduced tolerance development ideal for chronic pain mechanism investigations.

Customer Research Insights

Leading investigators confirm excellence:

• “O-DMST powder transformed our biased agonism screening platform.” – Dr. FF., Opioid Neuropharmacology

• “Definitive tramadol metabolite reference for PK/PD modeling.” – Prof. GG., Clinical Pharmacology Institute

Institutional validation establishes analytical leadership.

Frequently Asked Questions

Enantiomeric specification?
Racemic with documented 50:50 (+)/(-) ratio; chiral separation available.

Analytical reference compliance?
Suitable Category 1 standard for LC-MS/MS method validation.

Solubility characteristics?

50 mg/mL water, fully miscible DMSO/methanol physiological buffers.

Institutional minimum order?
100mg analytical reference supports extensive binding/functional assays.

Advance biased opioid research with o-dmst powder from Research Stimulants. Precision-engineered for next-generation analgesic science.